RHEL: How can I set up routes that are persistent?

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One way is to edit /etc/sysconfig/network-scripts/route-ethX (reflecting the ifcfg-ethX naming convention) and add the target network, netmask and gateway address.

ADDRESS0=192.168.1.0
NETMASK0=255.255.255.0
GATEWAY0=192.168.10.5
ADDRESS1=192.168.3.0
NETMASK1=255.255.255.0
GATEWAY1=192.168.10.5

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