Istio ingressgateway 503 responses with pilot displaying many error messages "ADS:EDS: ACK ERROR 10.128.89.30:41230 routerxxxx Internal:malformed IP address"

Solution Verified - Updated -

Issue

Istio ingressgateway connections getting HTTP 503 errors.
Pilot logs showing many messages like:

2021-07-23T13:53:11.041208Z warn ads ADS:EDS: ACK ERROR 10.131.0.28:38626 router~10.131.0.28~istio-egressgateway-5467d5584d-fd6d2.openshift-servicemesh~openshift-servicemesh.svc.cluster.local-32 (istio-egressgateway-5467d5584d-fd6d2.openshift-servicemesh) Internal:malformed IP address: github.com. Consider setting resolver_name or setting cluster type to 'STRICT_DNS' or 'LOGICAL_DNS'
2021-07-23T13:53:11.061181Z warn ads ADS:EDS: ACK ERROR 10.131.0.75:43158 router~10.131.0.75~istio-ingressgateway-dcfc49c46-7hp5x.openshift-servicemesh~openshift-servicemesh.svc.cluster.local-31 (istio-ingressgateway-dcfc49c46-7hp5x.openshift-servicemesh) Internal:malformed IP address: github.com. Consider setting resolver_name or setting cluster type to 'STRICT_DNS' or 'LOGICAL_DNS'

Environment

Openshift Container Platform 4.6+
Red Hat Openshift Service Mesh (OSSM) v1.1

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