HornetQException stating "Timed out waiting for response" in JBoss EAP

Issue

The following exception is happening often in our clustered environment. When it happens then the whole transaction which is currently executed fails.
The transaction involves saving entities to the database and sending messages about these changes to various queues and topics in HornetQ.

Subsequently, I see reattach requests and connection failures related to external clients

Can you please elaborate on the cause of this issue? How could we avoid it?

ERROR [org.hornetq.core.client.impl.ClientSessionImpl] (WorkerThread#4[IP:50533]) Caught Exception HornetQException[errorCode=3 message=Timed out waiting for response when sending packet 52]
 at org.hornetq.core.protocol.core.impl.ChannelImpl.sendBlocking(ChannelImpl.java:302)
 at org.hornetq.core.client.impl.ClientSessionImpl.end(ClientSessionImpl.java:1387)
 at org.hornetq.ra.HornetQRAXAResource.end(HornetQRAXAResource.java:113)
 at com.arjuna.ats.internal.jta.resources.arjunacore.XAResourceRecord.topLevelPrepare(XAResourceRecord.java:259)
 at com.arjuna.ats.arjuna.coordinator.BasicAction.doPrepare(BasicAction.java:2919)
 at com.arjuna.ats.arjuna.coordinator.BasicAction.doPrepare(BasicAction.java:2876)
 at com.arjuna.ats.arjuna.coordinator.BasicAction.prepare(BasicAction.java:2419)
 at com.arjuna.ats.arjuna.coordinator.BasicAction.End(BasicAction.java:1790)
 at com.arjuna.ats.arjuna.coordinator.TwoPhaseCoordinator.end(TwoPhaseCoordinator.java:94)
 at com.arjuna.ats.arjuna.AtomicAction.commit(AtomicAction.java:160)
 at com.arjuna.ats.internal.jta.transaction.arjunacore.TransactionImple.commitAndDisassociate(TransactionImple.java:1433)
 at com.arjuna.ats.internal.jta.transaction.arjunacore.BaseTransaction.commit(BaseTransaction.java:137)
 at com.arjuna.ats.jbossatx.BaseTransactionManagerDelegate.commit(BaseTransactionManagerDelegate.java:75)
 at org.jboss.aspects.tx.TxPolicy.endTransaction(TxPolicy.java:170)
 at org.jboss.aspects.tx.TxPolicy.invokeInOurTx(TxPolicy.java:87)
 at org.jboss.aspects.tx.TxInterceptor$Required.invoke(TxInterceptor.java:190)
 at org.jboss.aop.joinpoint.MethodInvocation.invokeNext(MethodInvocation.java:102)
 at org.jboss.aspects.tx.TxPropagationInterceptor.invoke(TxPropagationInterceptor.java:76)
 at org.jboss.aop.joinpoint.MethodInvocation.invokeNext(MethodInvocation.java:102)
 at org.jboss.aspects.remoting.ReplicantsManagerInterceptor.invoke(ReplicantsManagerInterceptor.java:52)
 at org.jboss.aop.joinpoint.MethodInvocation.invokeNext(MethodInvocation.java:102)
 at org.jboss.ejb3.security.RunAsSecurityInterceptorv2.invoke(RunAsSecurityInterceptorv2.java:94)
 at org.jboss.aop.joinpoint.MethodInvocation.invokeNext(MethodInvocation.java:102)
 at org.jboss.ejb3.security.RoleBasedAuthorizationInterceptorv2.invoke(RoleBasedAuthorizationInterceptorv2.java:201)
 at org.jboss.aop.joinpoint.MethodInvocation.invokeNext(MethodInvocation.java:102)
 at org.jboss.ejb3.security.Ejb3AuthenticationInterceptorv2.invoke(Ejb3AuthenticationInterceptorv2.java:182)
 at org.jboss.aop.joinpoint.MethodInvocation.invokeNext(MethodInvocation.java:102)
 at org.jboss.ejb3.ENCPropagationInterceptor.invoke(ENCPropagationInterceptor.java:41)
 at org.jboss.aop.joinpoint.MethodInvocation.invokeNext(MethodInvocation.java:102)
 at org.jboss.ejb3.BlockContainerShutdownInterceptor.invoke(BlockContainerShutdownInterceptor.java:67)
 at org.jboss.aop.joinpoint.MethodInvocation.invokeNext(MethodInvocation.java:102)
 at org.jboss.ejb3.core.context.CurrentInvocationContextInterceptor.invoke(CurrentInvocationContextInterceptor.java:47)
 at org.jboss.aop.joinpoint.MethodInvocation.invokeNext(MethodInvocation.java:102)
 at org.jboss.aspects.currentinvocation.CurrentInvocationInterceptor.invoke(CurrentInvocationInterceptor.java:67)
 at org.jboss.aop.joinpoint.MethodInvocation.invokeNext(MethodInvocation.java:102)
 at org.jboss.ejb3.interceptor.EJB3TCCLInterceptor.invoke(EJB3TCCLInterceptor.java:86)
 at org.jboss.aop.joinpoint.MethodInvocation.invokeNext(MethodInvocation.java:102)
 at org.jboss.ejb3.stateless.StatelessContainer.dynamicInvoke(StatelessContainer.java:363)
 at org.jboss.ejb3.session.InvokableContextClassProxyHack._dynamicInvoke(InvokableContextClassProxyHack.java:53)
 at org.jboss.aop.Dispatcher.invoke(Dispatcher.java:91)
 at org.jboss.aspects.remoting.AOPRemotingInvocationHandler.invoke(AOPRemotingInvocationHandler.java:82)
 at org.jboss.remoting.ServerInvoker.invoke(ServerInvoker.java:967)
 at org.jboss.remoting.transport.socket.ServerThread.completeInvocation(ServerThread.java:791)
 at org.jboss.remoting.transport.socket.ServerThread.processInvocation(ServerThread.java:744)
 at org.jboss.remoting.transport.socket.ServerThread.dorun(ServerThread.java:586)
 at org.jboss.remoting.transport.socket.ServerThread.run(ServerThread.java:234)86)
 at org.jboss.aop.joinpoint.MethodInvocation.invokeNext(MethodInvocation.java:102)
 at org.jboss.ejb3.stateless.StatelessContainer.dynamicInvoke(StatelessContainer.java:363)
 at org.jboss.ejb3.session.InvokableContextClassProxyHack._dynamicInvoke(InvokableContextClassProxyHack.java:53)
 at org.jboss.aop.Dispatcher.invoke(Dispatcher.java:91)
 at org.jboss.aspects.remoting.AOPRemotingInvocationHandler.invoke(AOPRemotingInvocationHandler.java:82)
 at org.jboss.remoting.ServerInvoker.invoke(ServerInvoker.java:967)
 at org.jboss.remoting.transport.socket.ServerThread.completeInvocation(ServerThread.java:791)
 at org.jboss.remoting.transport.socket.ServerThread.processInvocation(ServerThread.java:744)
 at org.jboss.remoting.transport.socket.ServerThread.dorun(ServerThread.java:586)
 at org.jboss.remoting.transport.socket.ServerThread.run(ServerThread.java:234)