gpg commands in RHEL 6 work fine, but print error: can't connect to `/home/user/.gnupg/S.gpg-agent': No such file or directory

Issue

• Most gpg encryption/decryption and sign/verify commands in RHEL 6 are printing the can't connect to '/home/user/.gnupg/S.gpg-agent' error, even when the operation seems to succeed
  Is this error a problem?
  Example 1:

  [root ~]# gpg --symmetric -o out.gpg --batch --passphrase 'mYp@55w0rd' /etc/redhat-release
  can't connect to `/root/.gnupg/S.gpg-agent': No such file or directory
  [root ~]# gpg --decrypt --batch --passphrase 'mYp@55w0rd' out.gpg
  gpg: 3DES encrypted data
  gpg: encrypted with 1 passphrase
  Red Hat Enterprise Linux Server release 6.6 (Santiago)
  gpg: WARNING: message was not integrity protected
  

  Example 2:

  [root ~]# gpg --sign -o out.gpg /etc/redhat-release
  
  You need a passphrase to unlock the secret key for
  user: "Moo Cow <moocow@devnull>"
  1024-bit RSA key, ID 43D67E41, created 2015-07-22
  
  can't connect to `/root/.gnupg/S.gpg-agent': No such file or directory
  
  ┌───────────────────────────────────────────────────────────────┐
  │ Please enter the passphrase to unlock the secret key for the  │
  │ OpenPGP certificate:                                          │
  │ "Moo Cow <moocow@devnull>"                                    │
  │ 1024-bit RSA key, ID 43D67E41,                                │
  │ created 2015-07-22.                                           │
  │                                                               │
  │ Passphrase **********________________________________________ │
  │                                                               │
  │         <OK>                                   <Cancel>       │
  └───────────────────────────────────────────────────────────────┘
  
  [root ~]# ll out.gpg
  -rw-r--r--. 1 root root 248 Jul 23 16:15 out.gpg
  [root ~]# gpg --verify out.gpg
  gpg: Signature made Thu 23 Jul 2015 04:15:29 PM EDT using RSA key ID 43D67E41
  gpg: Good signature from "Moo Cow <moocow@devnull>"