How to make configuration changes to serial port reboot resistant?

Issue

Currently when running "stty -a -F /dev/ttyS0" the output shows:

speed 115200 baud; rows 0; columns 0; line = 0;
intr = ^C; quit = ^\; erase = ^?; kill = ^U; eof = ^D; eol = <undef>;
eol2 = <undef>; swtch = <undef>; start = ^Q; stop = ^S; susp = ^Z; rprnt = ^R;
werase = ^W; lnext = ^V; flush = ^O; min = 1; time = 1;
-parenb -parodd cs8 hupcl -cstopb cread clocal crtscts -cdtrdsr
-ignbrk -brkint -ignpar -parmrk -inpck -istrip -inlcr -igncr -icrnl ixon -ixoff
-iuclc -ixany -imaxbel -iutf8
-opost -olcuc -ocrnl onlcr -onocr -onlret -ofill -ofdel nl0 cr0 tab0 bs0 vt0 ff0
-isig -icanon -iexten -echo -echoe -echok -echonl -noflsh -xcase -tostop -echoprt
echoctl echoke 

The option which needs to be changed is crtscts

We can disable it manually with "stty -F /dev/ttyS0 -crtscts" however after reboot the previous situation is present: crtscts

How to make it permanently to "-crtscts"?