Do I need to restart vsftpd when I modify configuration of tcp wrapper?

Issue

• Do I need to restart vsftpd when I modify configuration of tcp wrapper?
• Here are configuration files.

# grep -v ^# /etc/vsftpd/vsftpd.conf | grep -v ^$
anonymous_enable=NO
local_enable=YES
write_enable=YES
local_umask=027
dirmessage_enable=YES
xferlog_enable=YES
connect_from_port_20=YES
xferlog_std_format=YES
ascii_upload_enable=YES
ascii_download_enable=YES
listen=YES
pam_service_name=vsftpd
userlist_enable=YES
tcp_wrappers=YES
use_localtime=YES

# cat /etc/logrotate.d/vsftpd
/var/log/vsftpd.log {
    # ftpd doesn't handle SIGHUP properly
    nocompress
    missingok
}

/var/log/xferlog {
    # ftpd doesn't handle SIGHUP properly
    nocompress
    missingok
}