RHEV-H Swappiness

Hi,

We have a server with RHEV-H (Hypervisor) installed.
This server has 378GB of memory.

Swapness is configured as Linux default:

# sysctl -a | grep swap
vm.swappiness = 60

We do not intend to use more than 80% of server physical memory.
Could we use vm.swappiness = 0?

Is there any behavior or motivation to not use this configuration?

Regards