Why do I see "io_setup failed" when running multipath -ll in Red Hat Enterprise Linux?

Updated -

Release Found: Red Hat Enterprise Linux 4 and 5

Sometimes when running the command multipath -ll to display multipath maps and path statuses on a system that is configured to use the directio path checker, messages similar to the following appear:

$ multipath -ll
io_setup failed
io_setup failed
io_setup failed
io_setup failed
io_setup failed
...

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