What is a recommended region size for mirrored lvm volumes

Issue

• What is the recommended region size to use while creating mirror lvm volume of large size?
• Does the region size used in creation of mirror lvm volume would have any impact on performance?
• How to decide the region size for cluster mirror lvm volume of size up to 20 TB?
• Potentially encountering error below:

Unable to convert vg1 to clustered mode: Mirror region size of lv1 is too small.